Logo image
Back
Associations of Low Vitamin D and Elevated Parathyroid Hormone Concentrations With Bone Mineral Density in Perinatally HIV-Infected Children
Journal article   Open access   Peer reviewed

Associations of Low Vitamin D and Elevated Parathyroid Hormone Concentrations With Bone Mineral Density in Perinatally HIV-Infected Children

Denise L. Jacobson, Charles B. Stephensen, Tracie L. Miller, Kunjal Patel, Janet S. Chen, Russell B. Van Dyke, Ayesha Mirza, Gertrud U. Schuster, Rohan Hazra, Angela Ellis, …
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v 76(1), pp 33-42
01 Sep 2017
DOI: https://doi.org/10.1097/QAI.0000000000001467
PMID: 28797019
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc5624211View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Immunology Infectious Diseases Life Sciences & Biomedicine Science & Technology
Background: Perinatally HIV-infected (PHIV) children have, on average, lower bone mineral density (BMD) than perinatally HIV-exposed uninfected (PHEU) and healthy children. Low 25-hydroxy vitamin D [25(OH) D] and elevated parathyroid hormone (PTH) concentrations may lead to suboptimal bone accrual. Methods: PHIV and PHEU children in the Pediatric HIV/AIDS Cohort Study had total body (TB) and lumbar spine (LS) BMD and bone mineral content (BMC) measured by dual-energy x-ray absorptiometry; BMD z-scores (BMDz) were calculated for age and sex. Low 25(OH) D was defined as <= 20 ng/mL and high PTH as > 65 pg/mL. We fit linear regression models to estimate the average adjusted differences in BMD/BMC by 25(OH) D and PTH status and log binomial models to determine adjusted prevalence ratios of low 25(OH) D and high PTH in PHIV relative to PHEU children. Results: PHIV children (n = 412) were older (13.0 vs. 10.8 years) and more often black (76% vs. 64%) than PHEU (n = 207). Among PHIV, children with low 25(OH) D had lower TB-BMDz [SD, -0.38; 95% confidence interval (CI), -0.60 to -0.16] and TB-BMC (SD, -59.1 g; 95% CI, -108.3 to -9.8); high PTH accompanied by low 25(OH) D was associated with lower TB-BMDz. Among PHEU, children with low 25(OH) D had lower TB-BMDz (SD, -0.34; 95% CI, -0.64 to -0.03). Prevalence of low 25(OH) D was similar by HIV status (adjusted prevalence ratio, 1.00; 95% CI, 0.81 to 1.24). High PTH was 3.17 (95% CI, 1.25 to 8.06) times more likely in PHIV children. Conclusions: PHIV and PHEU children with low 25(OH) D may have lower BMD. Vitamin D supplementation trials during critical periods of bone accrual are needed.

Metrics

15 Record Views
14 citations in Web of Science
15 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Immunology
Infectious Diseases
Logo image