Journal article
Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci
American journal of epidemiology, v 181(6), pp 406-421
15 Mar 2015
PMID: 25713336
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regressionmodels tomeasure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increasedNHLrisk (OR = 3.27,95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).
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Details
- Title
- Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci
- Creators
- Sophia S. Wang - City Of Hope National Medical CenterClaire M. Vajdic - UNSW SydneyMartha S. Linet - National Institutes of HealthSusan L. Slager - Mayo Clinic Rochester, MNJenna Voutsinas - City Of Hope National Medical CenterAlexandra Nieters - University of FreiburgSilvia de Sanjose - Institut Català d'OncologiaWendy Cozen - University of Southern CaliforniaGraciela S. Alarcon - University of Alabama at BirminghamOtoniel Martinez-Maza - University of California at Los AngelesElizabeth E. Brown - University of Alabama at BirminghamPaige M. Bracci - University of California, San FranciscoTracy Lightfoot - University of YorkJennifer Turner - Macquarie UniversityHenrik Hjalgrim - Statens Serum InstitutJohn J. Spinelli - University of British ColumbiaTongzhang Zheng - Yale UniversityLindsay M. Morton - National Institutes of HealthBrenda M. Birmann - Harvard University ,Christopher R. Flowers - Emory UniversityOra Paltiel - Hebrew University of JerusalemNikolaus Becker - German Cancer Research CenterElizabeth A. Holly - University of California, San FranciscoEleanor Kane - University of YorkDennis Weisenburger - City of HopeMarc Maynadie - University of BurgundyPierluigi Cocco - University of CagliariLenka Foretova - Masaryk Memorial Cancer InstituteAnthony Staines - Dublin City UniversityScott Davis - University of WashingtonRichard Severson - Wayne State UniversityJames R. Cerhan - Mayo Clinic Rochester, MNElizabeth C. Breen - University of California at Los AngelesQing Lan - National Institutes of HealthAngela Brooks-Wilson - Simon Fraser UniversityAnneclaire J. De Roos - Drexel UniversityMartyn T. Smith - University of California, BerkeleyEve Roman - University of YorkPaolo Boffetta - Icahn School of Medicine at Mount SinaiAnne Kricker - University of SydneyYawei Zhang - Yale UniversityChristine Skibola - University of Alabama at BirminghamStephen J. Chanock - National Institutes of HealthNathaniel Rothman - National Institutes of HealthYolanda Benavente - Institut Català d'OncologiaPatricia Hartge - National Institutes of HealthKarin E. Smedby - Karolinska Institute
- Publication Details
- American journal of epidemiology, v 181(6), pp 406-421
- Publisher
- Oxford Univ Press
- Number of pages
- 16
- Grant note
- Intramural Research Program of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA DJCLS-R04/08 / Jose Carreras Leukemia Foundation University of Sydney Medical Foundation Program; University of Sydney Health Research Board, Ireland (EpiLymph) Compagnia di San Paolo-Programma Oncologia; Compagnia di San Paolo Fondazione Cariverona Cancer Council New South Wales QLK4-CT-2000-00422 / European Commission; European Commission Joint Research Centre CA45614; CA89745; CA87014; NO1-CO-12400; CA92153 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Leukaemia Research Fund Michael Smith Foundation for Health Research (British Columbia study) PI040091; PI041467 / Fondo Investigaciones Sanitarias; Instituto de Salud Carlos III R01CA154643; R03CA089745; R01CA062006; P30CA033572; R01CA045614; R01CA087014; R01CA092153; R01CA149445; P30CA016359; R03CA179558 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 03/09 / Network for Research in Epidemiology and Public Health Cancer Research, Ireland (InterLymph) CA17955801; CA033572 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA StSch4261; StSch4420 / Federal Office for Radiation Protection National Cancer Institute of Canada; Canadian Cancer Society (CCS) Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia CA62006 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000351508200007
- Scopus ID
- 2-s2.0-84924405081
- Other Identifier
- 991019168281204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health