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Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study
Journal article   Open access   Peer reviewed

Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study

Cheng Chen, Keming Yang, Hongmei Nan, Frederick Unverzagt, Leslie A McClure, Marguerite R Irvin, Suzanne Judd, Mary Cushman, Debora Kamin Mukaz, James E Klaunig, …
American journal of Alzheimer's disease and other dementias, v 38, pp 15333175231175797-15333175231175797
Jan 2023
PMID: 37340856
url
https://doi.org/10.1007/BF01474643View
Published, Version of Record (VoR)CC BY-NC-ND V4.0 Open
url
https://doi.org/10.1177/15333175231175797View
Published, Version of Record (VoR) Open

Abstract

racial disparity cognitive decline executive function, sex disparity telomere length
We examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race. A total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination 10 years later. Cognitive function was assessed by a four-test battery every 2 years. In multivariable-adjusted linear mixed models, longer baseline TL and smaller attrition/lengthening of TL over time were associated with better Animal Fluency Test score. Longer baseline TL was also linearly associated with better Letter Fluency Test score. The observed associations were consistently more pronounced in women than men and in Black compared to White participants. Telomere length may be a biomarker that predicts long-term verbal fluency and executive function, particularly in women and Black Americans.

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Geriatrics & Gerontology
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