Journal article
Associations of acculturation and kidney dysfunction among Hispanics and Chinese from the Multi-Ethnic Study of Atherosclerosis (MESA)
Nephrology, dialysis, transplantation, v 26(6), pp 1909-1916
04 Nov 2010
PMID: 21051500
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background.
Acculturation affects health, but it has never been studied with kidney disease.
Methods.
We studied the association of language spoken at home, generation and birth place with kidney function among Hispanics and Chinese in the Multi-Ethnic Study of Atherosclerosis (
n
= 2999). Kidney function was determined by cystatin C (eGFRcys) and albumin/creatinine ratio (ACR). We evaluated mediators in models: Model 1 = age, sex, income, education; Model 2 = Model 1 + behaviors; and Model 3 = Model 1 + comorbidities.
Results.
Among Hispanics, speaking mixed Spanish/English was significantly associated with lower eGFRcys (− 2.83 mL/min/1.73 m
2
, − 5.69–0.04) and higher ACR (RD 40%, 17–68%) compared with speaking Spanish only; this was mildly attenuated by behaviors (− 2.29, − 5.33–0.75; RD 42%, 18–72%) but not comorbidities (− 3.04, − 5.83 to − 0.23); RD 35%, 14–59%). US-born Hispanics had lower eGFRcys compared with foreign-born Hispanics [1.83 mL/min/1.73 m
2
lower (0.97–1.31) for Generation 1; 1.37 mL/min/1.73 m
2
lower (0.75–1.57) for Generation ≥ 2].
In contrast, Chinese who spoke any English had higher eGFRcys (2.53, 95% CI: − 1.70–6.78), but similar ACR (RD − 5%, 95% CI: − 26–23%) compared with those speaking Chinese only, but associations were not statistically significant.
Conclusion.
Higher acculturation was associated with worse kidney function in Hispanics, mediated perhaps by behavioral factors but not comorbidities. Associations may be in the opposite direction among Chinese. Future studies are needed to elucidate these mechanisms.
Metrics
Details
- Title
- Associations of acculturation and kidney dysfunction among Hispanics and Chinese from the Multi-Ethnic Study of Atherosclerosis (MESA)
- Creators
- Erica Chan Day - San Francisco VA Medical CenterYongmei Li - San Francisco VA Medical CenterAna Diez-Roux - University of MichiganNamratha Kandula - Northwestern UniversityAndrew Moran - Columbia UniversitySylvia Rosas - University of PennsylvaniaMichael G. Shlipak - San Francisco VA Medical CenterCarmen A. Peralta - San Francisco VA Medical Center
- Publication Details
- Nephrology, dialysis, transplantation, v 26(6), pp 1909-1916
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000292329100023
- Scopus ID
- 2-s2.0-79958129693
- Other Identifier
- 991020112073104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Transplantation
- Urology & Nephrology