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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma
Cancer epidemiology, v 33(3-4), pp 276-280
01 Oct 2009
PMID: 19736056
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: We examined risk of multiple myeloma (MM) associated with variants in genes involved in metabolism and response to exogenous chemicals [cytochrome P450 enzymes (CYP1B1, CYP20), epoxide hydrolase (EPHX1), paraoxonase 1 (PON1), arylhydrocarbon hydroxylase receptor (AHR), and NAD(P)H:quinone oxidoreductase (NQO1)]. Methods: This study included 279 MM cases and 782 controls in a pooled analysis of two population-based case-control studies. One common variant from each candidate gene was genotyped using DNA from blood or buccal cells. We estimated risk of MM associated with each genotype, controlling for race, gender, study site, and age, using odds ratios (OR) and 95% confidence intervals (CI). Results: Evaluations of the CYP1B1 V432L variant (rs1056836) suggested increased risk of MM among persons with the CG and GG genotypes compared to the CC genotype [OR (95% Cl) = 1.4 (1.0-2.0)]. Similar results were seen in analyses stratified by race and gender. We did not find any associations between MM and the CYP2C9, EPHX1, NQO1, or PON1 genes. Conclusions: CYP1B1 activates chemicals such as polycyclic aromatic hydrocarbons and dioxins to create oxidized, reactive intermediates, and higher gene activity has been shown for the G allele. We conducted the largest analysis to date on MM and these genetic variants and our results provide preliminary evidence that variation in CYP1B1 may influence susceptibility to MM. (C) 2009 Elsevier Ltd. All rights reserved.
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Details
- Title
- Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma
- Creators
- Laura S. Gold - University of WashingtonAnneclaire J. De Roos - University of WashingtonElizabeth E. Brown - University of AlabamaQing Lan - National Cancer InstituteKevin Milliken - University of WashingtonScott Davis - University of WashingtonStephen J. Chanock - National Cancer InstituteYawei Zhang - Yale UniversityRichard Severson - The Barbara Ann Karmanos Cancer InstituteSheila H. Zahm - National Cancer InstituteTongzhang Zheng - Yale UniversityNat Rothman - National Cancer InstituteDalsu Baris - National Cancer Institute
- Publication Details
- Cancer epidemiology, v 33(3-4), pp 276-280
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- Intramural Research Program of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ZIACP010123 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32ES07262 / National Institutes of Health, National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) T32ES007262 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000271784200019
- Scopus ID
- 2-s2.0-70349757186
- Other Identifier
- 991020100214704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health