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Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy
Journal article   Open access   Peer reviewed

Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy

Diana C. Pacyga, Marisa A. Patti, George D. Papandonatos, Diana K. Haggerty, Antonia M. Calafat, Joseph C. Gardiner, Joseph M. Braun, Susan L. Schantz and Rita S. Strakovsky
The Science of the total environment, v 855, 158788
10 Jan 2023
DOI: https://doi.org/10.1016/j.scitotenv.2022.158788
PMID: 36116648
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.scitotenv.2022.158788View
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Abstract

Environmental Sciences Environmental Sciences & Ecology Life Sciences & Biomedicine Science & Technology
Background/aims: Phthalates and their replacements are endocrine/metabolic disruptors that may impact gestational weight gain (GWG) - a pregnancy health indicator. We investigated overall and fetal sex-specific associations of individual and cumulative phthalate/replacement biomarkers with GWG. Methods: Illinois women (n= 299) self-reported their weight pre-pregnancy and at their final obstetric appointment before delivery (median 38 weeks). We calculated pre-pregnancy body mass index and gestational age-specific GWG z-scores (GWGz). We quantified 19 phthalate/replacement metabolites (representing 10 parent compounds) in pools of up-to-five first-morning urine samples, collected approximately monthly between 8 and 40 weeks gestation. We used linear regression, quantile-based g-computation (QGComp), and weighted quantile sum regression (WQSR) to evaluate associations of ten biomarkers (individual metabolites or parent molar-sums) individually or as mixtures (in interquartile range intervals) with GWGz. We evaluated associations in all women and stratified by fetal sex. Results: Individually, sums of metabolites of di(2-ethylhexyl) phthalate (Sigma DEHP), di(isononyl) cyclohexane-1,2 -dicarboxylate (Sigma DiNCH), and di(2-ethylhexyl) terephthalate (Sigma DEHTP) had consistent inverse associations with GWGz, and some associations were fetal sex-specific. When evaluating phthalates/replacements as a mixture, QGComp identified Sigma DEHP, Sigma DEHTP, and mono-(3-carboxypropyl) phthalate, along with sum of di(isononyl) phthalate metabolites (Sigma DiNP) and monobenzyl phthalate as notable contributors to lower and higher GWGz, respectively, resulting in a marginal inverse joint association in all women (beta: -0.29; 95% CI: -0.70, 0.12). In women carrying females, Sigma DEHP contributed to the marginal inverse joint association (beta: -0.54; 95% CI: -1.09, 0.03). However, there was no overall association in women carrying males (beta: 0.00; 95% CI: -0.60, 0.59), which was explained by approximately equal negative (driven by Sigma DEHTP) and positive (driven by Sigma DiNP) partial associations. WQSR analyses consistently replicated these QGComp findings. Conclusions: Biomarkers of phthalates/replacements were fetal sex-specifically associated with GWGz. Because Sigma DEHTP contributed substantively to mixture associations, additional studies in pregnant women may be needed around this plasticizer replacement.

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21 citations in Web of Science
19 citations in Scopus

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Environmental Sciences
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