Journal article
Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women's Health Initiative Observational Study
Cancer causes & control, v 35(9), pp 1283-1295
01 Sep 2024
PMID: 38772931
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hysterectomy is associated with subsequent changes in circulating hormone levels, but the evidence of an association for tubal ligation is unclear. We evaluated whether circulating concentrations of androgens and estrogens differ by tubal ligation or hysterectomy status in postmenopausal women from the Women's Health Initiative (WHI)-Observational Study (OS).
Serum androgens and estrogens were measured in 920 postmenopausal women who did not use menopausal hormone therapy at the time of blood draw, of whom 139 self-reported a history of tubal ligation and 102 reported hysterectomy (with intact ovaries). Geometric mean hormone concentrations (GMs) and 95% confidence intervals (CIs) associated with a history of tubal ligation or hysterectomy (ever/never), as well as time since procedures, were estimated using adjusted linear regression with inverse probability of sampling weights to account for selection.
Circulating levels of 12 androgen/androgen metabolites and 20 estrogen/estrogen metabolites did not differ by tubal ligation status. Among women reporting prior hysterectomy compared to women without hysterectomy, we observed lower levels of several androgens (e.g., testosterone (nmol/L): GM
0.46 [95% CI:0.37-0.57] vs. GM
0.62 [95% CI:0.53-0.72]) and higher levels of estrogen metabolites, for example, 2-hydroxyestrone-3-methyl ether (GM
11.1 [95% CI:8.95-13.9] pmol/L vs. GM
8.70 [95% CI:7.38-10.3]) and 4-methoxyestrone (GM
6.50 [95% CI:5.05-8.37] vs. GM
4.92 [95% CI:4.00-6.05]).
While we did not observe associations between prior tubal ligation and postmenopausal circulating hormone levels, our findings support that prior hysterectomy was associated with lower circulating testosterone levels and higher levels of some estrogen metabolites, which may have implications for future hormone-related disease risks.
Metrics
1 Record Views
Details
- Title
- Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women's Health Initiative Observational Study
- Creators
- Ashley M Geczik - United States Department of Health and Human ServicesKara A Michels - United States Department of Health and Human ServicesGarnet L Anderson - Fred Hutch Cancer CenterRoni T Falk - United States Department of Health and Human ServicesLeslie V Farland - University of ArizonaJoAnn E Manson - Harvard UniversityAladdin H Shadyab - University of California San DiegoRuth M Pfeiffer - United States Department of Health and Human ServicesXia Xu - Leidos (United States)Britton Trabert - United States Department of Health and Human Services
- Publication Details
- Cancer causes & control, v 35(9), pp 1283-1295
- Publisher
- Springer Nature
- Grant note
- P30 CA016058 / NCI NIH HHS HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS HHSN268201100003I / NHLBI NIH HHS ZIA CP010126 / Intramural NIH HHS Z01 CP010126 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:001228558800001
- Scopus ID
- 2-s2.0-85193693781
- Other Identifier
- 991022202512504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health