Journal article
Associative encoding and retrieval are predicted by functional connectivity in distinct hippocampal area CA1 pathways
The Journal of neuroscience, v 34(34), pp 11188-11198
20 Aug 2014
PMID: 25143600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Determining how the hippocampus supports the unique demands of memory encoding and retrieval is fundamental for understanding the biological basis of episodic memory. One possibility proposed by theoretical models is that the distinct computational demands of encoding and retrieval are accommodated by shifts in the functional interaction between the hippocampal CA1 subregion and its input structures. However, empirical tests of this hypothesis are lacking. To test this in humans, we used high-resolution fMRI to measure functional connectivity between hippocampal area CA1 and regions of the medial temporal lobe and midbrain during extended blocks of associative encoding and retrieval tasks. We found evidence for a double dissociation between the pathways supporting successful encoding and retrieval. Specifically, during the associative encoding task, but not the retrieval task, functional connectivity only between area CA1 and the ventral tegmental area predicted associative long-term memory. In contrast, connectivity between area CA1 and DG/CA3 was greater, on average, during the retrieval task compared with the encoding task, and, importantly, the strength of this connectivity significantly correlated with retrieval success. Together, these findings serve as an important first step toward understanding how the demands of fundamental memory processes may be met by changes in the relative strength of connectivity within hippocampal pathways.
Metrics
Details
- Title
- Associative encoding and retrieval are predicted by functional connectivity in distinct hippocampal area CA1 pathways
- Creators
- Katherine Duncan - Columbia UniversityAlexa Tompary - Department of Psychology andLila Davachi - New York University
- Publication Details
- The Journal of neuroscience, v 34(34), pp 11188-11198
- Publisher
- Society for Neuroscience
- Grant note
- Canadian Institutes of Health Research MH074692 / NIMH NIH HHS R01 MH074692 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000341312600004
- Scopus ID
- 2-s2.0-84906213304
- Other Identifier
- 991021448188404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences