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Journal article
Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs
Frontiers in aging neuroscience, v 9, pp 281-281
29 Aug 2017
PMID: 28900395
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
With the advent of highly active antiretroviral therapy (HAART) survival rates among patients infected by HIV have increased. However, even though survival has increased HIV-associated neurocognitive disorders (HAND) still persist, suggesting that HAART-drugs may play a role in the neurocognitive impairment observed in HIV-infected patients. Given previous data demonstrating that astrocyte senescence plays a role in neurocognitive disorders such as Alzheimer's disease (AD), we examined the role of HAART on markers of senescence in primary cultures of human astrocytes (HAs). Our results indicate HAART treatment induces cell cycle arrest, senescence-associated beta-galactosidase, and the cell cycle inhibitor p21. Highly active antiretroviral therapy treatment is also associated with the induction of reactive oxygen species and upregulation of mitochondrial oxygen consumption. These changes in mitochondria correlate with increased glycolysis in HAART drug treated astrocytes. Taken together these results indicate that HAART drugs induce the senescence program in HAs, which is associated with oxidative and metabolic changes that could play a role in the development of HAND.
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Details
- Title
- Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs
- Creators
- Justin Cohen - Drexel UniversityLuca D'Agostino - Drexel UniversityJoel Wilson - Drexel UniversityFerit Tuzer - Drexel UniversityClaudio Torres - Drexel University
- Publication Details
- Frontiers in aging neuroscience, v 9, pp 281-281
- Publisher
- Frontiers Media Sa
- Number of pages
- 12
- Grant note
- R01NS078283 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R21AG046943 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) 1RO1NS078283; NS78283; R21AG046943; F31AG054191 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000409166100001
- Scopus ID
- 2-s2.0-85041710618
- Other Identifier
- 991019168522404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology
- Neurosciences