Journal article
Astrocyte activation and fibrous gliosis: glial fibrillary acidic protein immunostaining of astrocytes following intraspinal cord grafting of fetal CNS tissue
Progress in brain research, v 71, pp 439-455
01 Jan 1987
PMID: 3588961
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This chapter highlights some basic facts pertaining to glial intermediate filaments with emphasis on the chemistry and metabolism of their major constituent protein, glial fibrillary acidic protein (GFAP). Gliosis is usually characterized by extensive astroglial proliferation and hypertrophy. In addition, reactive astrocytes undergo numerous cytological and histochemical features, including increases in nuclear diameter, elevated DNA levels, an accumulation of intermediate filaments, heightened oxidoreductive enzyme activity, and increased synthesis of GFAP, vimentin, glutamine synthetase, and glycogen. In principle, fibrous gliosis can be considered as a part of an important healing response to a central nervous system (CNS) injury because astrocytes are thought to actively monitor and control the contents of the extracellular space of the CNS, including the amounts of ions, transmitters, trophic factors, nutrients, and waste materials. They also play a role in the removal of myelin and neuronal debris and encapsulate the regions of the CNS that are exposed to non-CNS tissue environments following trauma. The most prominent characteristic of fibrous gliosis is an extensive synthesis of intermediate filaments.
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Details
- Title
- Astrocyte activation and fibrous gliosis: glial fibrillary acidic protein immunostaining of astrocytes following intraspinal cord grafting of fetal CNS tissue
- Creators
- Lawrence F. Eng - Stanford University School of MedicinePaul J. Reier - University of FloridaJohn D. Houle - University of Florida
- Publication Details
- Progress in brain research, v 71, pp 439-455
- Publisher
- Elsevier
- Number of pages
- 17
- Grant note
- R01NS011632 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) NS-11632; NSA-13836; NS-22316 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000207653600038
- Scopus ID
- 2-s2.0-0023086915
- Other Identifier
- 991020545233904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences