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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Astrocyte modulation of extinction impairments in ethanol-dependent female mice
Neuropharmacology, v 179, 108272
15 Nov 2020
PMID: 32801026
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rates of alcohol use disorders are increasing in women, and there is growing evidence that both the cognitive and biological consequences of alcohol dependence are distinct in women as compared to men. Despite this, the neurobehavioral outcomes of chronic alcohol exposure are poorly characterized in women and female animals. In this study, we find that ethanol dependence impaired extinction of reward seeking in a food conditioned place preference task in female mice. At the same time point, ethanol-dependent females exhibited astrocytic dysregulation as indicated by a brain region-specific reduction in glial fibrillary acidic protein (GFAP) expression. Using a chemogenetic strategy, we demonstrate that modulating astrocyte function via chemogenetic activation of Gq-signaling in nucleus accumbens astrocytes transiently rescued extinction in ethanol-dependent females without impacting basal reward seeking. These findings identify astrocyte function as a potential target for the restoration of behavioral flexibility following chronic alcohol exposure in females.
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Details
- Title
- Astrocyte modulation of extinction impairments in ethanol-dependent female mice
- Creators
- Laura L. Giacometti - Drexel UniversityKelsey Chandran - Drexel UniversityLaura A. Figueroa - Drexel UniversityJacqueline M. Barker - Drexel University
- Publication Details
- Neuropharmacology, v 179, 108272
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- AA024499 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Hartwell Foundation Postdoctoral Fellowship
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000579725500008
- Scopus ID
- 2-s2.0-85089674843
- Other Identifier
- 991019169900204721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy