Journal article
Astroglial nuclear factor-kappa B regulates learning and memory and synaptic plasticity in female mice
Journal of neurochemistry, v 104(3), pp 611-623
01 Feb 2008
PMID: 17953667
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Astrocytes play a pivotal role in regulating synaptic plasticity and synapse formation. The nuclear factor-kappa B (NF-kappa B) family of transcription factors has recently been demonstrated to be an important modulator of synaptic plasticity and learning/memory. In this study, we investigated the role of astroglial NF-kappa B in synaptic plasticity and learning/memory using transgenic mice over-expressing an N-terminal truncated form of inhibitor of NF-kappa B alpha (I kappa B alpha) in astrocytes (GFAP-I kappa Beta alpha-dn). We demonstrated that female transgenic mice, but not males, have robust deficits in hippocampal and extra-hippocampal-dependent learning and memory. We also determined that there are significant deficits in LTP and expression of metabotropic glutamate receptor 5 and post-synaptic density protein 95 (PSD95) in female transgenic mice. These findings indicate that astroglial NF-kappa B is an important regulator of learning/memory and synaptic plasticity.
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Details
- Title
- Astroglial nuclear factor-kappa B regulates learning and memory and synaptic plasticity in female mice
- Creators
- Valerie Bracchi-Ricard - University of MiamiRoberta Brambilla - Miami Project to Cure ParalysisJonathan Levenson - University of Wisconsin–MadisonWen-Hui Hu - Virginia Commonwealth University Medical CenterAnnmarie Bramwell - University of MiamiDavid Sweatt - University of AlabamaEdward J. Green - University of MiamiJohn R. Bethea - University of Miami
- Publication Details
- Journal of neurochemistry, v 104(3), pp 611-623
- Publisher
- Wiley
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000252322600004
- Scopus ID
- 2-s2.0-38049117573
- Other Identifier
- 991020099869004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences