Journal article
Asymmetric Synthesis and Properties of Sulfinimines (Thiooxime S-Oxides)
Journal of organic chemistry, v 62(8), pp 2555-2563
18 Apr 1997
PMID: 11671597
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Enantiomerically pure sulfinimines (thiooxime S-oxides 10), important building blocks in the asymmetric synthesis of amine derivatives, are prepared in good to excellent yields in one step from aromatic, heteroaromatic, and aliphatic aldehydes. This protocol involves treating commercially available (R)- or (S)-menthyl p-toluenesufinate (Andersen reagent 4) with LiHMDS, followed by the aldehyde, affording (E)-10 exclusively. The sulfinimines 10 are formed via a Peterson-type olefination reaction of silylsulfinamide anion 13 with the aldehyde. Anion 13 is generated by reaction of lithium menthoxide (12a) with bis(trimethylsilyl)sulfinamide 11, which is formed in the reaction of 4 with LiHMDS. The other product formed is O-(trimethylsilyl)menthol (12c), which is isolated in >80% yield for recycling. Two other less efficient methods for the asymmetric synthesis of 10 are discussed: (i) the asymmetric oxidation of sulfenimines 6 with chiral nonracemic oxaziridines and (ii) the reaction of metal aldimines, prepared from nitriles, with 4. All of these protocols fail with ketones.
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Details
- Title
- Asymmetric Synthesis and Properties of Sulfinimines (Thiooxime S-Oxides)
- Creators
- Franklin A. Davis - Drexel UniversityRajarathnam E. Reddy - Drexel UniversityJoanna M. Szewczyk - Drexel UniversityG. Venkat Reddy - Drexel UniversityPadma S. Portonovo - Drexel UniversityHuiming Zhang - Drexel UniversityDean Fanelli - Drexel UniversityR. Thimma ReddyPing Zhou - Drexel UniversityPatrick J. Carroll - Drexel University
- Publication Details
- Journal of organic chemistry, v 62(8), pp 2555-2563
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1997WU86000047
- Scopus ID
- 2-s2.0-0000574262
- Other Identifier
- 991019168392904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Organic