Journal article
Asymmetric synthesis of the antibiotic (+)-thiamphenicol using cis-N-( p-toluenesulfinyl)aziridine 2-carboxylic acids
Tetrahedron letters, v 35(41), pp 7525-7528
1994
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A concise, highly efficient asymmetric synthesis of aminopropanediol (1R,2R)-(−)-
3, precursor to the broad spectrum antibiotics thiamphenicol/florfenicol
1
2
, was prepared in two steps from cis-aziridine 2-carboxylic acid (2S,3S)-(−)-
5.
The key intermediate in the asymmetric synthesis of the broad spectrum antibiotic thiamphenicol (+)-
1, aminopropanediol (−)-
3, was prepared in two steps from cis-N-(
p-toluenesulfinyl)aziridine 2-carboxylic acid (−)-
5.
Metrics
Details
- Title
- Asymmetric synthesis of the antibiotic (+)-thiamphenicol using cis-N-( p-toluenesulfinyl)aziridine 2-carboxylic acids
- Creators
- Franklin A Davis - Drexel UniversityPing Zhou - Drexel University
- Publication Details
- Tetrahedron letters, v 35(41), pp 7525-7528
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1994PL49600010
- Scopus ID
- 2-s2.0-0028139165
- Other Identifier
- 991019173884604721
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- Web of Science research areas
- Chemistry, Organic