Journal article
At the leading edge of three-dimensional cell migration
Journal of cell science, v 125(Pt 24), pp 5917-5926
15 Dec 2012
PMID: 23378019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cells migrating on flat two-dimensional (2D) surfaces use actin polymerization to extend the leading edge of the plasma membrane during lamellipodia-based migration. This mode of migration is not universal; it represents only one of several mechanisms of cell motility in three-dimensional (3D) environments. The distinct modes of 3D migration are strongly dependent on the physical properties of the extracellular matrix, and they can be distinguished by the structure of the leading edge and the degree of matrix adhesion. How are these distinct modes of cell motility in 3D environments related to each other and regulated? Recent studies show that the same type of cell migrating in 3D extracellular matrix can switch between different leading edge structures. This mode-switching behavior, or plasticity, by a single cell suggests that the apparent diversity of motility mechanisms is integrated by a common intracellular signaling pathway that governs the mode of cell migration. In this Commentary, we propose that the mode of 3D cell migration is governed by a signaling axis involving cell-matrix adhesions, RhoA signaling and actomyosin contractility, and that this might represent a universal mechanism that controls 3D cell migration.
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Details
- Title
- At the leading edge of three-dimensional cell migration
- Creators
- Ryan J Petrie - National Institute of Dental and Craniofacial ResearchKenneth M Yamada - National Institute of Dental and Craniofacial Research
- Publication Details
- Journal of cell science, v 125(Pt 24), pp 5917-5926
- Publisher
- Company of Biologists
- Grant note
- Z01 DE000524 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000315590300002
- Scopus ID
- 2-s2.0-84875580811
- Other Identifier
- 991020099677304721
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- Web of Science research areas
- Cell Biology