Journal article
Atherosclerosis risk factors in systemic lupus erythematosus
Current rheumatology reports, v 11(4), pp 241-247
Aug 2009
PMID: 19691926
Abstract
Cardiovascular disease (CVD) has emerged as a leading cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Growing evidence suggests that inflammation plays a key role in the pathogenesis of atherosclerosis from initial endothelial dysfunction to rupture of atheromatous plaques. The increased frequency of atherosclerosis in SLE is likely due to a complex interplay among traditional risk factors, disease-related factors such as medications and disease activity, and inflammatory and immunogenic factors. Identification of these novel risk factors will lead to a better understanding of CVD pathogenesis and may also provide targets for potential treatment strategies. When caring for SLE patients, clinicians should be aware of the increased CVD risk and treat the known modifiable risk factors in addition to controlling disease activity and inflammation.
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18 citations in Scopus
Details
- Title
- Atherosclerosis risk factors in systemic lupus erythematosus
- Creators
- Surabhi Agarwal - University of PittsburghJennifer R ElliottSusan Manzi
- Publication Details
- Current rheumatology reports, v 11(4), pp 241-247
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Scopus ID
- 2-s2.0-70449674696
- Other Identifier
- 991021933899804721