Journal article
Atomic force microscopic and theoretical studies of poly-ubiquitin proteins
Chemical physics letters, v 399(4), pp 440-445
2004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this Letter, a theoretical model for the force–extension experiment applied to protein folding–unfolding is presented. This model explicitly takes into account the interplay between the mechanical energy and chemical energy. It can treat the effect of denaturing agents (like pH, GdnHCl, urea, etc.) and temperature on the force–extension experiment of protein folding–unfolding. We further apply the model to analyze our own force–extension experiment on ubiquitin tetramers and to the experimental data of other protein systems reported in literature. The current model can predict the quantities like the values of equilibrium constant, chemical potential and mole fraction of unfolded state involved in protein folding–unfolding and we have found that the proteins adsorbed on gold surfaces are partially unfolded in comparison with the bulk state.
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Details
- Title
- Atomic force microscopic and theoretical studies of poly-ubiquitin proteins
- Creators
- Y.L. Yeh - Institute of Atomic and Molecular Sciences, Academia SinicaC.H. Chang - Institute of Atomic and Molecular Sciences, Academia SinicaK.-K. Liang - Institute of Atomic and Molecular Sciences, Academia SinicaY.-J. Shiu - Institute of Atomic and Molecular Sciences, Academia SinicaCharlene Su - Institute of Atomic and Molecular Sciences, Academia SinicaM. Hayashi - National Taiwan UniversityC.L. Chyan - National Dong Hwa UniversityG. Yang - Drexel UniversityYan Mo - Hong Kong University of Science and TechnologyYiJing Yan - Hong Kong University of Science and TechnologyS.H. Lin - National Taiwan University
- Publication Details
- Chemical physics letters, v 399(4), pp 440-445
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mathematics
- Web of Science ID
- WOS:000225389800027
- Scopus ID
- 2-s2.0-19944399101
- Other Identifier
- 991019168369304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Physical
- Physics, Atomic, Molecular & Chemical