Journal article
Atovaquone resistance in malaria parasites
Drug resistance updates, v 3(5)
Oct 2000
PMID: 11498396
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atovaquone is a broad-spectrum antiparasitic agent active against malaria, Pneumocystis carinii pneumonia, toxoplasmosis and babesiosis. When used as a single agent, resistance to atovaquone arose rapidly in falciparum malaria, requiring the development of a new antimalarial drug combination of atovaquone and proguanil. Recent laboratory investigations have provided insights into the mode of atovaquone action, and identified the molecular basis for the resistance development. Mutations within a catalytic domain of the cytochrome bc1complex present within the parasite mitochondrial inner membrane were shown to be responsible for atovaquone resistance. Here, we review these studies and propose a mechanism by which atovaquone resistance may arise quickly in malaria parasites.
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Details
- Title
- Atovaquone resistance in malaria parasites
- Creators
- Akhil B VaidyaMichael W Mather
- Publication Details
- Drug resistance updates, v 3(5)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000165686400005
- Scopus ID
- 2-s2.0-0033646097
- Other Identifier
- 991014878455304721
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- Web of Science research areas
- Pharmacology & Pharmacy