Journal article
Attenuation of Forkhead signaling by the retinal determination factor DACH1
Proceedings of the National Academy of Sciences - PNAS, v 107(15), pp 6864-6869
13 Apr 2010
PMID: 20351289
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Drosophila Dachshund (Dac) gene, cloned as a dominant inhibitor of the hyperactive growth factor mutant ellipse, encodes a key component of the retinal determination gene network that governs cell fate. Herein, cyclic amplification and selection of targets identified a DACH1 DNA-binding sequence that resembles the FOX (Forkhead box-containing protein) binding site. Genome-wide in silico promoter analysis of DACH1 binding sites identified gene clusters populating cellular pathways associated with the cell cycle and growth factor signaling. ChIP coupled with high-throughput sequencing mapped DACH1 binding sites to corresponding gene clusters predicted in silico and identified as weight matrix resembling the cyclic amplification and selection of targets-defined sequence. DACH1 antagonized FOXM1 target gene expression, promoter occupancy in the context of local chromatin, and contact-independent growth. Attenuation of FOX function by the cell fate determination pathway has broad implications given the diverse role of FOX proteins in cellular biology and tumorigenesis.
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Details
- Title
- Attenuation of Forkhead signaling by the retinal determination factor DACH1
- Creators
- Jie Zhou - Thomas Jefferson UniversityChenguang Wang - Thomas Jefferson UniversityZhibin Wang - National Heart Lung and Blood InstituteWill Dampier - Drexel University, School of Biomedical Engineering, Science, and Health SystemsKongming Wu - Thomas Jefferson UniversityMathew C Casimiro - Thomas Jefferson UniversityIouri Chepelev - National Heart Lung and Blood InstituteVladimir M Popov - Thomas Jefferson UniversityAndrew Quong - Thomas Jefferson UniversityAydin Tozeren - Drexel University, School of Biomedical Engineering, Science, and Health SystemsKeji Zhao - National Heart Lung and Blood InstituteMichael P Lisanti - Thomas Jefferson UniversityRichard G Pestell - Thomas Jefferson University
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 107(15), pp 6864-6869
- Publisher
- PNAS; United States
- Number of pages
- 6
- Grant note
- R01 AR055660 / NIAMS NIH HHS R01 CA120876 / NCI NIH HHS R01 CA080250 / NCI NIH HHS R01 CA075503 / NCI NIH HHS R01CA080250 / NCI NIH HHS R01CA86072 / NCI NIH HHS P30 CA056036 / NCI NIH HHS R01CA120876 / NCI NIH HHS R01CA75503 / NCI NIH HHS Intramural NIH HHS R01 CA086072 / NCI NIH HHS R01CA70896 / NCI NIH HHS P30CA56036 / NCI NIH HHS R01 CA098779 / NCI NIH HHS R01CA098779 / NCI NIH HHS R01 CA070896 / NCI NIH HHS R01AR055660 / NIAMS NIH HHS 232240 / PHS HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000276642100056
- Scopus ID
- 2-s2.0-77951070784
- Other Identifier
- 991014878110104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology