Journal article
Attenuation of cocaine-induced genomic and functional responses in prenatal cocaine-exposed rabbits
Pharmacology, biochemistry and behavior, v 69(1-2), pp 225-232
May 2001
PMID: 11420090
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of in utero cocaine exposure on cocaine-induced genomic and functional responses in postnatal life were examined. Pregnant Dutch Belted rabbits were injected intravenously, twice daily, with cocaine hydrochloride (4 mg/kg) or saline from day 8 through day 29 of pregnancy. Prenatally exposed kits were challenged with cocaine on postnatal day 20. In prenatal saline-exposed kits, cocaine induced time- and dose-dependent c-fos gene expression in both frontal cortex and striatum. Prenatal cocaine exposure reduced cocaine-induced c-fos responses by 35-58% in the frontal cortex and 37-41% in the striatum. Cocaine-induced functional responses that included head bobbing, seizure, and locomotor activity were also attenuated in prenatal cocaine-exposed kits. Cocaine-induced c-fos expression and functional responses were blocked by the D(1) dopamine receptor antagonist, SCH23390, or by the serotonin receptor antagonist, methysergide, but not by the D(2) dopamine receptor antagonist, L-sulpride. The results indicate that in utero cocaine exposure leads to diminished responses to cocaine challenge in the offspring, which may be mediated by prenatal cocaine-induced alterations in one or more components of the D(1) dopamine and/or serotonin receptor signaling systems during early postnatal life.
Metrics
Details
- Title
- Attenuation of cocaine-induced genomic and functional responses in prenatal cocaine-exposed rabbits
- Creators
- N Tilakaratne - Laboratory of Molecular Pharmacology, Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA.G Cai - Laboratory of Molecular Pharmacology, Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA.E Friedman - Laboratory of Molecular Pharmacology, Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA.
- Publication Details
- Pharmacology, biochemistry and behavior, v 69(1-2), pp 225-232
- Publisher
- Elsevier
- Grant note
- DA 11029 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000169425100029
- Scopus ID
- 2-s2.0-0034992348
- Other Identifier
- 991019168757104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy