Journal article
Attenuation of the locomotor activating effects of D-amphetamine, cocaine, and scopolamine by potassium channel modulators
Progress in neuro-psychopharmacology & biological psychiatry, v 21(5), pp 853-872
01 Jul 1997
PMID: 9278956
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Abstract
1.
1. Locomotor activating effects of
d
-amphetamine, cocaine, and scopolamine were determined alone and after pretreatment with K-channel modulators in mice.
2.
2. When administered alone,
d
-amphetamine (1.0–30 mg/kg) and cocaine (3.0–56 mg/kg) produced inverted U-shaped dose-effect curves characteristic of psychomotor stimulant drugs.
3.
3. When administered alone, scopolamine (3.0–56 mg/kg) also produced dose-dependent increases in locomotor activity but these effects plateaued with similar increases in locomotor activity induced by 10–56 mg/kg of scopolamine.
4.
4. Pretreatment with the K-channel blockers 4-aminopyridine (0.3–1.7 mg/kg), quinine (30–100 mg/kg) or apamin (0.3–1.0 mg/kg) attenuated the locomotor increases induced by d-amphetamine, cocaine, and scopolamine.
5.
5. Like the K-channel blockers, pretreatment with the K-channel openers cromakalim (1.0–3.0 mg/kg) and pinacidil (3.0–10 mg/kg) also attenuated the locomotor increases induced by
d
-amphetamine and scopolamine but did not modify the locomotor activating effects of cocaine.
6.
6. These results demonstrate that K-channel modulation modifies the effects of damphetamine, cocaine, and scopolamine.
7.
7. The results also demonstrate that K-channel openers can differentially alter the behavioral effects of cocaine and
d
-amphetamine.
Metrics
Details
- Title
- Attenuation of the locomotor activating effects of D-amphetamine, cocaine, and scopolamine by potassium channel modulators
- Creators
- Sharon Rosenzweig-LipsonShirley ThomasJames E. Barrett
- Publication Details
- Progress in neuro-psychopharmacology & biological psychiatry, v 21(5), pp 853-872
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; Neurology
- Web of Science ID
- WOS:A1997XP39100010
- Scopus ID
- 2-s2.0-0030876060
- Other Identifier
- 991020836371104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry