Journal article
Atypical pathways of NF-κB activation and aging
Experimental gerontology, v 44(4)
2009
PMID: 19174186
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The eukaryotic transcription factor Nuclear Factor-κB (NF-κB) is a master regulator for inflammatory responses, mediating cellular defense against infectious agents and environmental and cellular stress. However, recent evidence-based studies have demonstrated that constitutive activation of NF-κB is a ubiquitous phenomenon among various cell types in the aging phenotype, contributing deleterious effects that oppose the acutely beneficial effects of NF-κB seen in the inflammatory response. Expression of NF-κB with age is consistent with elevated levels of inflammatory markers and a pro-inflammatory phenotype, manifested in many age-associated diseases. While inducible activating mechanisms for NF-κB in the innate immune response are well characterized, constitutive activation in aging cells warrants further investigation of mechanisms collectively called atypical pathways. In this review, we provide a comprehensive examination of such NF-κB activating mechanisms, including mitochondrial dysfunction, endoplasmic stress response, organelle cross-talk, secondary messengers and DNA damage. Investigation of mechanisms of NF-κB in aging as an important marker of cellular stress provides guidance for the development of a systems view of cellular aging.
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Details
- Title
- Atypical pathways of NF-κB activation and aging
- Creators
- Andres Kriete - Drexel UniversityKelli L Mayo - Rutgers, The State University of New Jersey
- Publication Details
- Experimental gerontology, v 44(4)
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000265340600003
- Scopus ID
- 2-s2.0-62349092245
- Other Identifier
- 991014877937204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology