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Augmentation of integrin-mediated mechanotransduction by hyaluronic acid
Journal article   Open access   Peer reviewed

Augmentation of integrin-mediated mechanotransduction by hyaluronic acid

Anant Chopra, Maria E. Murray, Fitzroy J. Byfield, Melissa G. Mendez, Ran Halleluyan, David J. Restle, Dikla Raz-Ben Aroush, Peter A. Galie, Katarzyna Pogoda, Robert Bucki, …
Biomaterials, v 35(1), pp 71-82
01 Jan 2014
DOI: https://doi.org/10.1016/j.biomaterials.2013.09.066
PMID: 24120037
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3930571View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Engineering Engineering, Biomedical Materials Science Materials Science, Biomaterials Science & Technology Technology
Changes in tissue and organ stiffness occur during development and are frequently symptoms of disease. Many cell types respond to the stiffness of substrates and neighboring cells in vitro and most cell types increase adherent area on stiffer substrates that are coated with ligands for integrins or cadherins. In vivo cells engage their extracellular matrix (ECM) by multiple mechanosensitive adhesion complexes and other surface receptors that potentially modify the mechanical signals transduced at the cell/ECM interface. Here we show that hyaluronic acid (also called hyaluronan or HA), a soft polymeric glycosaminoglycan matrix component prominent in embryonic tissue and upregulated during multiple pathologic states, augments or overrides mechanical signaling by some classes of integrins to produce a cellular phenotype otherwise observed only on very rigid substrates. The spread morphology of cells on soft HA-fibronectin coated substrates, characterized by formation of large actin bundles resembling stress fibers and large focal adhesions resembles that of cells on rigid substrates, but is activated by different signals and does not require or cause activation of the transcriptional regulator YAP. The fact that HA production is tightly regulated during development and injury and frequently upregulated in cancers characterized by uncontrolled growth and cell movement suggests that the interaction of signaling between HA receptors and specific integrins might be an important element in mechanical control of development and homeostasis. (C) 2013 Elsevier Ltd. All rights reserved.

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103 citations in Web of Science
109 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Engineering, Biomedical
Materials Science, Biomaterials
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