Journal article
Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth
CANCERS, v 12(2), 460
Feb 2020
PMID: 32079164
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The goal of our study was to measure the kinetics of human colorectal cancer (CRC) development in order to identify aberrant mechanisms in tissue dynamics and processes that contribute to colon tumorigenesis. The kinetics of tumor development were investigated using age-at-tumor diagnosis (adenomas and CRCs) of familial adenomatous coli (FAP) patients and sporadic CRC patients. Plots of age-at-tumor diagnosis data as a function of age showed a distinct sigmoidal-shaped curve that is characteristic of an autocatalytic reaction. Consequently, we performed logistics function analysis and found an excellent fit (p < 0.05) of the logistic equation to the curves for age-at-tumor diagnoses. These findings indicate that the tissue mechanism that becomes altered in CRC development and growth involves an autocatalytic reaction. We conjecture that colonic epithelium normally functions as a polymer of cells which dynamically maintains itself in a steady state through an autocatalytic polymerization mechanism. Further, in FAP and sporadic CRC patients, mutation in the adenomatous polyposis coli (APC) gene increases autocatalytic tissue polymerization and induces tumor tissues to autocatalyze their own progressive growth, which drives tumor development in the colon.
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Details
- Title
- Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth
- Publication Details
- CANCERS, v 12(2), 460
- Publisher
- MDPI; BASEL
- Grant note
- Funding for this project was provided through generous support from The Lisa Dean Moseley Foundation (B. M. Boman), Cancer B*Ware Foundation (B. M. Boman), CATX Inc. (R. M. Boman), Drexel University Student Scholarship (R. M. Boman) and the Center for Translational Cancer Research (B. M. Boman).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000522477300206
- Scopus ID
- 2-s2.0-85079685686
- Other Identifier
- 991021860772904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology