Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth
Cancers, v 12(2), 460
17 Feb 2020
PMID: 32079164
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The goal of our study was to measure the kinetics of human colorectal cancer (CRC) development in order to identify aberrant mechanisms in tissue dynamics and processes that contribute to colon tumorigenesis. The kinetics of tumor development were investigated using age-at-tumor diagnosis (adenomas and CRCs) of familial adenomatous coli (FAP) patients and sporadic CRC patients. Plots of age-at-tumor diagnosis data as a function of age showed a distinct sigmoidal-shaped curve that is characteristic of an autocatalytic reaction. Consequently, we performed logistics function analysis and found an excellent fit (p < 0.05) of the logistic equation to the curves for age-at-tumor diagnoses. These findings indicate that the tissue mechanism that becomes altered in CRC development and growth involves an autocatalytic reaction. We conjecture that colonic epithelium normally functions as a polymer of cells which dynamically maintains itself in a steady state through an autocatalytic polymerization mechanism. Further, in FAP and sporadic CRC patients, mutation in the adenomatous polyposis coli (APC) gene increases autocatalytic tissue polymerization and induces tumor tissues to autocatalyze their own progressive growth, which drives tumor development in the colon.
Metrics
Details
- Title
- Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth
- Creators
- Bruce M. Boman - Helen F Graham Canc Ctr & Res Inst, Ctr Translat Canc Res, Newark, DE 19718 USAArthur Guetter - Hamline UniversityRyan M. Boman - Drexel UniversityOlaf A. Runquist - Hamline University
- Publication Details
- Cancers, v 12(2), 460
- Publisher
- Mdpi
- Number of pages
- 13
- Grant note
- CATX Inc. Cancer B*Ware Foundation Center for Translational Cancer Research Drexel University Student Scholarship Lisa Dean Moseley Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000522477300206
- Scopus ID
- 2-s2.0-85079685686
- Other Identifier
- 991021860772904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology