Journal article
Autocrine factors, type IV collagenase secretion and prostatic cancer cell invasion
Cancer and metastasis reviews, v 12(1)
01 Mar 1993
PMID: 8448826
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Motility factors play a major role in tumor cell invasion and metastases. The biochemical properties of various motility factors; the receptor mediated mechanism of action; the role of microtubules; the potential influence of oncogenes; and the influence of motility factors on type IV collagenase secretion and invasion are discussed. We report on expression of a 70 kDa motility factor, termed invasion stimulating factor (ISF), in human prostatic PC-3 sublines. Boyden chamber chemotactic assays and measurements of type IV collagenase synthesis and secretion suggest that an ISF-receptor dependent mechanism influences tumor cell invasion and protease secretion. Taken together, the evidence that autocrine motility factors play an essential role in tumor cell invasion and metastases is compelling.
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Details
- Title
- Autocrine factors, type IV collagenase secretion and prostatic cancer cell invasion
- Creators
- Mark E. Stearns - Drexel UniversityMona Stearns - Drexel University
- Publication Details
- Cancer and metastasis reviews, v 12(1)
- Publisher
- Springer Nature
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:A1993KL05300006
- Scopus ID
- 2-s2.0-0027472435
- Other Identifier
- 991020876805704721
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- Web of Science research areas
- Oncology