Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Autologous Serum Eye Drops in the Management of Limbal Stem Cell Deficiency Associated With Glaucoma Surgery
Eye & contact lens, v 49(1), pp 19-24
01 Jan 2023
PMID: 36322388
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose:To evaluate safety and efficacy of autologous serum eye drops (AS) in the treatment of limbal stem cell deficiency (LSCD) associated with glaucoma surgery.Methods:Retrospective case series of eyes with glaucoma surgery-induced LSCD treated with AS. Diagnosis of LSCD was confirmed by anterior segment optical coherence tomography, in vivo confocal microscopy, and/or impression cytology. Limbal stem cell deficiency severity was staged using a clinical scoring system (2-10 points). Outcome measures were changes (>= 2 points) of the LSCD score and best-corrected visual acuity (BCVA) from the baseline to the last follow-up.Results:Thirteen eyes of 12 consecutive patients treated with 50% AS for at least 3 months were included. The mean age was 78.9 +/- 7.5 years and the mean duration of AS use was 20.9 +/- 16.8 months. Indications of AS included LSCD progression in eight eyes (61.5%) and visual axis threatening in five eyes (38.5%). The mean LSCD score at baseline (6.7 +/- 1.6) was similar to that at last follow-up (6.5 +/- 2.2, P=0.625). Two eyes (15.4%) showed improvement, nine eyes (69.2%) were stable, and two eyes (15.4%) worsened. The mean baseline BCVA (0.89 +/- 0.64 logMAR) was similar to the mean final BCVA (1.05 +/- 0.63 logMAR, P=0.173). There were no serious adverse complications related to AS.Conclusion:AS appears to be well tolerated and may stabilize the progression of LSCD with limited effects. A larger study is necessary to confirm the findings.
Metrics
Details
- Title
- Autologous Serum Eye Drops in the Management of Limbal Stem Cell Deficiency Associated With Glaucoma Surgery
- Creators
- Duangratn Niruthisard - College Station Medical CenterClemence Bonnet - College Station Medical CenterLokachet Tanasugarn - Mahidol UniversityBryan Le - Drexel UniversitySophie X. Deng - College Station Medical Center
- Publication Details
- Eye & contact lens, v 49(1), pp 19-24
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- R01 EY021797; R01 EY028557 / National Eye Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) Prevent Blindness; Research to Prevent Blindness (RPB) TR2-01768; CLIN1-08686; CLIN2-11650 / California Institute for Regenerative Medicine R01EY021797; R01EY028557 / National Eye Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) Department of Ophthalmology, Banphaeo General Hospital, Samut Sakhon, Thailand
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000901834600004
- Scopus ID
- 2-s2.0-85144594751
- Other Identifier
- 991021861180804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology