Journal article
Autonomic Neural Control of Cardiac Function: Modulation by Adenosine and Adenosine 5′-Triphosphate
The American journal of cardiology, v 79(12)
19 Jun 1997
PMID: 9223357
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adenosine and adenosine 5′-triphosphate (ATP) are found in every cell of the human body. These molecules are released from cells into the extracellular fluid under physiologic and pathophysiologic conditions. Outside of cells, adenosine and ATP act as physiologic regulators of cells, tissues, and organs. In the heart, extracellular adenosine and ATP exert pronounced inotropic, lusitropic, electrophysiologic, and metabolic effects, which are mediated by specific cell surface receptors. In addition, both compounds can modulate sympathetic and parasympathetic input to the heart by interacting with neural elements within and without the heart, thereby modulating autonomic neural control of cardiac functions. This article briefly reviews these indirect, neurally-mediated actions of adenosine and ATP.
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Details
- Title
- Autonomic Neural Control of Cardiac Function: Modulation by Adenosine and Adenosine 5′-Triphosphate
- Creators
- Amir Pelleg - Allegheny University of the Health SciencesGuennadi Katchanov - Allegheny University of the Health SciencesJiang Xu - Allegheny University of the Health Sciences
- Publication Details
- The American journal of cardiology, v 79(12)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1997XN83200003
- Scopus ID
- 2-s2.0-0030812076
- Other Identifier
- 991019348753904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems