Journal article
Axon regeneration and exercise‐dependent plasticity after spinal cord injury
Annals of the New York Academy of Sciences, v 1279(1)
Mar 2013
PMID: 23531013
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Current dogma states that meaningful recovery of function after spinal cord injury (SCI) will likely require a combination of therapeutic interventions comprised of regenerative/neuroprotective transplants, addition of neurotrophic factors, elimination of inhibitory molecules, functional sensorimotor training, and/or stimulation of paralyzed muscles or spinal circuits. We routinely use (1) peripheral nerve grafts to support and direct axonal regeneration across an incomplete cervical or complete thoracic transection injury, (2) matrix modulation with chondroitinase (ChABC) to facilitate axonal extension beyond the distal graft–spinal cord interface, and (3) exercise, such as forced wheel walking, bicycling, or step training on a treadmill. We and others have demonstrated an increase in spinal cord levels of endogenous neurotrophic factors with exercise, which may be useful in facilitating elongation and/or synaptic activity of regenerating axons and plasticity of spinal neurons below the level of injury.
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Details
- Title
- Axon regeneration and exercise‐dependent plasticity after spinal cord injury
- Creators
- John D Houle - Drexel University College of MedicineMarie‐Pascale Côté - Drexel University College of Medicine
- Publication Details
- Annals of the New York Academy of Sciences, v 1279(1)
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- NIH (NS26380; NS055976; NS074406)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000325688000017
- Scopus ID
- 2-s2.0-84875582206
- Other Identifier
- 991014878127404721
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- Web of Science research areas
- Neurosciences