Journal article
Axon-target interactions in the developing cerebellum
Perspectives on developmental neurobiology, v 5(1), pp 69-82
1997
PMID: 9509519
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
After entering target regions, afferent growth cones grow among putative target cells, stop extending upon meeting target cells, and transit into a synaptic ending. During these events, signals are transmitted to and from target cells to stimulate programs of differentiation. Here we describe three approaches to unraveling mechanisms of these phases of synaptogenesis. First, dye-labeling in the intact cerebellum has revealed the orchestration of afferent ingrowth and contacts with target cells. Second, an in vitro model based on purified granule neurons has shed light on the role of target cells in the arrest of afferent extension. Third, coculture of purified granule neurons (parallel fiber afferents) with purified Purkinje cells has demonstrated facets of afferent regulation of target cell differentiation. These analyses have suggested molecular mechanisms that mediate maturation of afferents and their targets.
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Details
- Title
- Axon-target interactions in the developing cerebellum
- Creators
- C A Mason - Columbia UniversityM E Morrison - Columbia UniversityM S Ward - Columbia UniversityQ Zhang - Columbia UniversityD H Baird - Drexel University, Allegheny University of the Health Sciences (1996-1998)
- Publication Details
- Perspectives on developmental neurobiology, v 5(1), pp 69-82
- Publisher
- United States
- Number of pages
- 14
- Grant note
- R01 NS 16951 / NINDS NIH HHS F32 NS09864 / NINDS NIH HHS NS33214 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Intensive Medical Sciences (IMS)
- Web of Science ID
- WOS:000071898600007
- Scopus ID
- 2-s2.0-0031416882
- Other Identifier
- 991014878023004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Developmental Biology
- Neurosciences