Logo image
Back
Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements
Journal article   Open access   Peer reviewed

Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements

Tanuja T Merianda, Cynthia Gomes, Soonmoon Yoo, Deepika Vuppalanchi and Jeffery L Twiss
The Journal of neuroscience, v 33(34), pp 13735-13742
21 Aug 2013
DOI: https://doi.org/10.1523/jneurosci.0962-13.2013
PMID: 23966695
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1523/jneurosci.0962-13.2013View
Published, Version of Record (VoR)CC BY-NC-SA V4.0,  Open

Abstract

3' Untranslated Regions - physiology 5' Untranslated Regions - physiology Analysis of Variance Animals Axons - metabolism Cells, Cultured Ganglia, Spinal - cytology Gene Expression Regulation - physiology Hippocampus - cytology Male Membrane Proteins - genetics Membrane Proteins - metabolism Microtubule-Associated Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - metabolism Photobleaching Rats Rats, Sprague-Dawley RNA, Messenger - metabolism RNA, Small Interfering - pharmacology tau Proteins - metabolism Transfection
Many neuronal mRNAs are actively transported into distal axons. The 3' untranslated regions (UTRs) of axonal mRNAs often contain cues for their localization. The 3' UTR of neuritin mRNA was shown to be sufficient for localization into axons of hippocampal neurons. Here, we show that neuritin mRNA localizes into axons of rat sensory neurons, but this is predominantly driven by the 5' rather than 3' UTR. Neuritin mRNA shifts from cell body to axon predominantly after nerve crush injury, suggesting that it encodes a growth-associated protein. Consistent with this, overexpression of neuritin increases axon growth but only when its mRNA localizes into the axons.

Metrics

3 Record Views
48 citations in Web of Science
48 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Neurosciences
Logo image