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Journal article
Axonal transcription factors signal retrogradely in lesioned peripheral nerve
The EMBO journal, v 31(6), pp 1350-1363
21 Mar 2012
PMID: 22246183
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin alpha 5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus.
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Details
- Title
- Axonal transcription factors signal retrogradely in lesioned peripheral nerve
- Creators
- Keren Ben-Yaakov - Weizmann Institute of ScienceShachar Y. Dagan - Weizmann Institute of ScienceYael Segal-Ruder - Weizmann Institute of ScienceOphir Shalem - Weizmann Institute of ScienceDeepika Vuppalanchi - University of DelawareDianna E. Willis - Burke Medical Research InstituteDmitry Yudin - Weizmann Institute of ScienceIda Rishal - Weizmann Institute of ScienceFranziska Rother - Max Delbrück CenterMichael Bader - Max Delbrück CenterArmin Blesch - University of California San DiegoYitzhak Pilpel - Weizmann Institute of ScienceJeffery L. Twiss - Drexel UniversityMike Fainzilber - Weizmann Institute of Science
- Publication Details
- The EMBO journal, v 31(6), pp 1350-1363
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- 1157/09 / Israel Science Foundation R01NS041596 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01-NS041596; K99-NR010797 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K99NR010797 / NATIONAL INSTITUTE OF NURSING RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) 1010-168.1/2008 / German-Israeli Foundation; German-Israeli Foundation for Scientific Research and Development 2003208 / US-Israel Binational Science Foundation P86; P116 / International Foundation for Research in Paraplegia Dr Miriam and Sheldon G Adelson Medical Research Foundation KO 1950/3-1 / Deutsche Forschungsgemeinschaft; German Research Foundation (DFG)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000302131600004
- Scopus ID
- 2-s2.0-84858799332
- Other Identifier
- 991021892106204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology