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Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
Cancer epidemiology, biomarkers & prevention, v 31(5), pp 1103-1110
04 May 2022
PMID: 35244686
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes.
In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression.
We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08-1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59-2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell-mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction.
Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions.
Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.
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Details
- Title
- B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
- Creators
- Sophia S Wang - City of HopeClaire M Vajdic - UNSW SydneyMartha S Linet - National Cancer InstituteSusan L Slager - Mayo Clinic, Rochester, MN, United States.Jenna Voutsinas - City Of Hope National Medical CenterAlexandra Nieters - University of FreiburgDelphine Casabonne - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaJames R Cerhan - Mayo Clinic, Rochester, MN, United States.Wendy Cozen - University of California, IrvineGraciela Alarcón - University of Alabama at Birmingham HospitalOtoniel Martínez-Maza - University of California, Los AngelesElizabeth E Brown - University of Alabama at BirminghamPaige M Bracci - University of California, San FranciscoJennifer Turner - Douglass Hanly Moir PathologyHenrik Hjalgrim - Statens Serum InstitutParveen Bhatti - BC Cancer Research CentreYawei Zhang - Department of Cancer Prevention and Control at the National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, China.Brenda M Birmann - Brigham and Women's HospitalChristopher R Flowers - The University of Texas MD Anderson Cancer CenterOra Paltiel - Hadassah Medical CenterElizabeth A Holly - University of California, San FranciscoEleanor Kane - University of YorkDennis D Weisenburger - City Of Hope National Medical CenterMarc Maynadié - University of BurgundyPierluigi Cocco - University of CagliariLenka Foretova - Masaryk Memorial Cancer InstituteElizabeth Crabb Breen - University of California, Los AngelesQing Lan - National Cancer InstituteAngela Brooks-Wilson - BC Cancer Research CentreAnneclaire J De Roos - Drexel UniversityMartyn T Smith - University of California, BerkeleyEve Roman - University of YorkPaolo Boffetta - Stony Brook UniversityAnne Kricker - University of SydneyTongzhang Zheng - Brown University, United States.Christine F Skibola - Emory UniversityJacqueline Clavel - University of ParisAlain Monnereau - Sorbonne Paris CitéStephen J Chanock - National Cancer InstituteNathaniel Rothman - National Cancer InstituteYolanda Benavente - Catalan Institut of Oncology, IDIBELL, Barcelona, Spain.Patricia Hartge - National Cancer InstituteKarin E Smedby - Karolinska Institute
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 31(5), pp 1103-1110
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- R01 CA092153 / NCI NIH HHS CA45614 / NCI NIH HHS R01 CA154643 / NCI NIH HHS R01 CA200703 / NCI NIH HHS R01 CA062006 / NCI NIH HHS NO1-CO-12400 / NIH HHS N01 PC067008 / NCI NIH HHS N01 PC065064 / NCI NIH HHS 051210 / European Commission P30 CA015083 / NCI NIH HHS CB06/02/0073 / European Regional Development Fund R01 CA087014 / NCI NIH HHS LO1413 / MEYS - NPS I StSch4261 / Federal Office for Radiation Protection grants N01-PC-65064 / NCI NIH HHS HHSN261201000140C / NCI NIH HHS N01CO12400 / NCI NIH HHS 5R01 CA69669-02 / NIH HHS 2017SGR1085 / AGENCIA DE GESTIO D'AJUTS UNIVERSITARIS I DE RECERCA R03 CA179558 / NIH HHS 20110209 / Stockholm County Council N01 PC067010 / NCI NIH HHS CA62006 / NCI NIH HHS R03 CA179558 / NCI NIH HHS R01 CA045614 / NCI NIH HHS R01 CA92153 / NIH HHS DJCLS-R12/23 / José Carreras Leukemia Foundation BMBF-01-EO-1303 / German Federal Ministry for Education and Research ID990920 / Australian National Health and Medical Research Council QLK4-CT-2000-00422 / European Commission R03 CA089745 / NCI NIH HHS 02 6661 / Swedish Cancer Society R21 CA165923 / NCI NIH HHS 00209805 / Health Research Board, Ireland and Cancer Research Ireland N01 PC067009 / NCI NIH HHS 2009/659 / Swedish Cancer Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000796704100001
- Scopus ID
- 2-s2.0-85130190242
- Other Identifier
- 991019168189904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health