Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
BKCa (Slo) Channel Regulates Mitochondrial Function and Lifespan in Drosophila melanogaster
Cells (Basel, Switzerland), v 8(9), p945
01 Sep 2019
PMID: 31438578
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BKCa channels, originally discovered in Drosophila melanogaster as slowpoke (slo), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BKCa channels in cellular and organ protection possibly for their ability to modulate mitochondrial function. However, the direct role of BKCa channels in regulating mitochondrial structure and function is not deciphered. Here, we demonstrate that BKCa channels are present in fly mitochondria, and slo mutants show structural and functional defects in mitochondria. slo mutants display an increase in reactive oxygen species and the modulation of ROS affected their survival. We also found that the absence of BKCa channels reduced the lifespan of Drosophila, and overexpression of human BKCa channels in flies extends life span in males. Our study establishes the presence of BKCa channels in mitochondria of Drosophila and ascertains its novel physiological role in regulating mitochondrial structural and functional integrity, and lifespan.
Metrics
Details
- Title
- BKCa (Slo) Channel Regulates Mitochondrial Function and Lifespan in Drosophila melanogaster
- Creators
- Shubha Gururaja Rao - Drexel UniversityPiotr Bednarczyk - Warsaw University of Life SciencesAtif Towheed - Children's Hospital of PhiladelphiaKajol Shah - Drexel UniversityPriyanka Karekar - Drexel UniversityDevasena Ponnalagu - Drexel UniversityHaley N. Jensen - The Ohio State University Wexner Medical CenterSankar Addya - Thomas Jefferson UniversityBeverly A. S. Reyes - Drexel UniversityElisabeth J. Van Bockstaele - Drexel UniversityAdam Szewczyk - Nencki Institute of Experimental BiologyDouglas C. Wallace - Children's Hospital of PhiladelphiaHarpreet Singh - Drexel University
- Publication Details
- Cells (Basel, Switzerland), v 8(9), p945
- Publisher
- Mdpi
- Number of pages
- 19
- Grant note
- OD10944 / Department of Defense; United States Department of Defense 16GRNT29430000 / American Heart Association NS021328; CA182384; MH108592; HL133050 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Commonwealth Universal Research Enhancement (CURE) Program 17POST33670360 / American Heart Association Postdoctoral Fellowship; American Heart Association 11SDG230059 / American Heart Association National Scientist Development Grant; American Heart Association P40OD018537 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA W. W. Smith Charitable Trust P40OD018537 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Drexel University College of Medicine startup funds R01HL133050 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000489103800004
- Scopus ID
- 2-s2.0-85072226495
- Other Identifier
- 991019185111404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology