Journal article
BLACK RICE ANTHOCYANINS AMELIORATE RETINAL PHOTOCHEMICAL DAMAGE IN RAT VIA ANTI-OXIDATION AND ANTI-APOPTOSIS
Current topics in nutraceuticals research, v 10(3-4), pp 165-172
01 Aug 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It was established that black rice anthocyanins (BRACs) provided potent anti-oxidative and anti-apoptotic effects wherever in vitro or in vivo. In this stay, the protective effects of BRACs against retinal photochemical damage and the mechanisms that might be associated were investigated in SpragueDawley rats. Sixty rats were assigned randomly to two groups, which were treated with (n=30) or without BRAGS (n=30) by intragastric administration for 15d respectively. Then both groups were exposed to 3000 +/- 200 lux fluorescent light for 0 similar to 24h. After treatments, the cytoprotective role and antioxdant effects of BRAG were assessed in retinas. Our result showed that the light exposure resulted in severely functional and structural damage in retinas. And supplementary of BRAG effectively prevented injure as previously stated and maintained its normal function and structure. Furthermore, supplementary BRAG markedly reduced the photoreceptor cells apoptosis induced by light stress (P<0.05), and also decreased malondialdehyde level (P<0.05) and elevated the activities of superoxide dismutase (SOD), glutathione S-transferase (GST) and glutathione peroxidase (GSH-PX) in retinas (P<0.05). In conclusion, these result suggested that supplementation with BRAG can effectively protect the retina against photochemical damage in rats, which may be due in mostly to its potent antioxidant and anti-apoptotic capacity.
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Details
- Title
- BLACK RICE ANTHOCYANINS AMELIORATE RETINAL PHOTOCHEMICAL DAMAGE IN RAT VIA ANTI-OXIDATION AND ANTI-APOPTOSIS
- Creators
- Wei Chen - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaHao Jia - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaXiaoping Yu - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaXiuhua Wu - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaMantian Mi - Third Mil Med Univ, Sch Prevent Med, Dept Nutr & Food Hyg, Chongqing 400038, Peoples R ChinaLongjian Liu - Drexel UniversityShuai Li - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaHong Liu - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaJiru Liao - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaMin Yang - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R ChinaWeihua Liu - Chengdu Med Coll, Dept Publ Hlth, Chengdu 610083, Peoples R China
- Publication Details
- Current topics in nutraceuticals research, v 10(3-4), pp 165-172
- Publisher
- New Century Health Publishers, Llc
- Number of pages
- 8
- Grant note
- 30972462 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) KYTD201012 / innovative science research team of Sichuan Province NCET-08-0901 / New Century Excellent Talents in University; Program for New Century Excellent Talents in University (NCET) SYS11-004 / "development and regeneration" key laboratory of Sichuan Province
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000208909500003
- Other Identifier
- 991019170450704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics
- Pharmacology & Pharmacy