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BORG family proteins in physiology and human disease
Journal article   Open access   Peer reviewed

BORG family proteins in physiology and human disease

Meagan R. Tomasso and Shae B. Padrick
Cytoskeleton (Hoboken, N.J.)
05 Jul 2023
DOI: https://doi.org/10.1002/cm.21768
PMID: 37403807
url
https://doi.org/10.1002/cm.21768View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Cell Biology Life Sciences & Biomedicine Science & Technology
The binder of rho GTPases (BORG)/Cdc42 effector proteins (Cdc42EP) family is composed of five Rho GTPase binding proteins whose functions and mechanism of actions are of emerging interest. Here, we review recent findings pertaining to the family as a whole and consider how these change our understanding of cellular organization. Recent studies have implicated BORGs in both fundamental physiology and in human diseases, mainly cancers. An emerging pattern suggests that BORG family members cancer-promoting properties are related to their ability to regulate the cytoskeleton, with many impacting the organization of acto-myosin stress fibers. This is consistent with the broader literature indicating that BORG family members are regulators of both the septin and actin cytoskeleton networks. The exact mechanism through which BORGs modify the cytoskeleton is not clear, but we consider here a few data-supported and speculative possibilities. Finally, we delve into how the Rho GTPase Cdc42 modifies BORG function in cells. This remains open-ended as Cdc42's effects on BORGs appear cell type- and cell state-dependent. Collectively, these data point to the importance of the BORG family and suggest broader themes in their function and regulation.

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3 citations in Web of Science
3 citations in Scopus

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Cell Biology
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