Journal article
BORG family proteins in physiology and human disease
Cytoskeleton (Hoboken, N.J.)
05 Jul 2023
PMID: 37403807
Abstract
The binder of rho GTPases (BORG)/Cdc42 effector proteins (Cdc42EP) family is composed of five Rho GTPase binding proteins whose functions and mechanism of actions are of emerging interest. Here, we review recent findings pertaining to the family as a whole and consider how these change our understanding of cellular organization. Recent studies have implicated BORGs in both fundamental physiology and in human diseases, mainly cancers. An emerging pattern suggests that BORG family members cancer-promoting properties are related to their ability to regulate the cytoskeleton, with many impacting the organization of acto-myosin stress fibers. This is consistent with the broader literature indicating that BORG family members are regulators of both the septin and actin cytoskeleton networks. The exact mechanism through which BORGs modify the cytoskeleton is not clear, but we consider here a few data-supported and speculative possibilities. Finally, we delve into how the Rho GTPase Cdc42 modifies BORG function in cells. This remains open-ended as Cdc42's effects on BORGs appear cell type- and cell state-dependent. Collectively, these data point to the importance of the BORG family and suggest broader themes in their function and regulation.
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Details
- Title
- BORG family proteins in physiology and human disease
- Creators
- Meagan R. Tomasso - Drexel UniversityShae B. Padrick - Drexel University
- Publication Details
- Cytoskeleton (Hoboken, N.J.)
- Publisher
- Wiley
- Number of pages
- 17
- Grant note
- Department of Biochemistry and Molecular Biology, College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:001022755600001
- Scopus ID
- 2-s2.0-85164470756
- Other Identifier
- 991020836512904721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology