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Journal article
BPD Following Preterm Birth: A Model for Chronic Lung Disease and a Substrate for ARDS in Childhood
Frontiers in pediatrics, v 4, pp 60-60
15 Jun 2016
PMID: 27379219
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It has been suggested that pediatric acute respiratory distress syndrome (PARDS) may be a different entity, vis-a-vis adult acute respiratory distress syndrome (ARDS), based on its epidemiology and outcomes. A more pediatric-specific definition of PARDS to include the subgroup of patients with underlying lung (and heart) disease has been proposed. Epidemiological data suggest that up to 13% of the children with ARDS have a history of prematurity and/or underlying chronic lung disease. However, the specific contribution of bronchopulmonary dysplasia (BPD), the most common chronic lung disease in infants, to the development of PARDS is not known. BPD leads to damaged lungs with long-term consequences secondary to disordered growth and immune function. These damaged lungs could potentially act as a substrate, which given the appropriate noxious stimuli, can predispose a child to PARDS. Interestingly, similar biomarkers [KL-6, interleukin (IL)-6, IL-8, sICAM-1, angiopoietin-2, and matrix metalloproteinase-8 and -9] of pulmonary injury have been associated both with BPD and ARDS. Recognition of a unique pattern of clinical symptomatology and/or outcomes of PARDS, if present, could potentially be useful for investigating targeted therapeutic interventions.
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Details
- Title
- BPD Following Preterm Birth: A Model for Chronic Lung Disease and a Substrate for ARDS in Childhood
- Creators
- Anita Bhandari - Connecticut Children's Medical CenterChristopher Carroll - Connecticut Children's Medical CenterVineet Bhandari - Drexel University
- Publication Details
- Frontiers in pediatrics, v 4, pp 60-60
- Publisher
- Frontiers Media Sa
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science; Pediatrics
- Web of Science ID
- WOS:000377746900001
- Scopus ID
- 2-s2.0-85055218798
- Other Identifier
- 991019169624804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics