Journal article
Baclofen Withdrawal Following Removal of an Intrathecal Baclofen Pump Despite Oral Baclofen Replacement
Journal of toxicology. Clinical toxicology, v 41(1), pp 83-85
2003
PMID: 12645974
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.
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Details
- Title
- Baclofen Withdrawal Following Removal of an Intrathecal Baclofen Pump Despite Oral Baclofen Replacement
- Creators
- Michael I. Greenberg - Drexel UniversityRobert G. Hendrickson - Washington Poison Center
- Publication Details
- Journal of toxicology. Clinical toxicology, v 41(1), pp 83-85
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:000181380900015
- Scopus ID
- 2-s2.0-0037288057
- Other Identifier
- 991019168444104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Toxicology