Journal article
Bacterial meningitis: non-antibiotic modes of therapy
Current opinion in infectious diseases, v 6(5), pp 638-638
Oct 1993
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bacterial meningitis remains common and devastating; despite recent advances in antimicrobial therapy, the overall morbidity and mortality remains high. Recent advances in the understanding of the pathogenesis and pathophysiology of bacterial meningitis have led to the development of innovative treatment strategies in the hopes of improving outcome from this disorder. Studies in animal models have demonstrated that attenuation of the subarachnoid space inflammatory response by anti-inflammatory agents may be useful in preventing many of the pathophysiologic consequences of bacterial meningitis such as cerebral edema and increased intracranial pressure. In addition, several recent clinical trials have shown that the anti-inflammatory agent dexamethasone is beneficial in certain patients with bacterial meningitis. Administration of adjunctive dexamethasone, in conjunction with antimicrobial agents, is recommended for infants and children with Haemophilus influenzae type b meningitis. Pending the results of ongoing studies, adjunctive dexamethasone is not recommended in adults, in infants less than 2 months old, or in patients with meningitis caused by bacteria other than H. influenzae. Other agents that reduce subarachnoid space inflammation, specifically monoclonal antibodies directed against the CD18 family of leukocyte receptors, may also prove to be beneficial in improving outcome in patients with bacterial meningitis.
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Details
- Title
- Bacterial meningitis: non-antibiotic modes of therapy
- Creators
- Allan Tunkel - Division of Infectious Diseases, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA
- Publication Details
- Current opinion in infectious diseases, v 6(5), pp 638-638
- Publisher
- Lippincott-Raven Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:A1993LY80600004
- Scopus ID
- 2-s2.0-0027246627
- Other Identifier
- 991019346808804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Infectious Diseases