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Bactericidal activity of ramoplanin against antibiotic-resistant enterococci
Journal article   Open access   Peer reviewed

Bactericidal activity of ramoplanin against antibiotic-resistant enterococci

C C Johnson, S Taylor, P Pitsakis, P May and M E Levison
Antimicrobial agents and chemotherapy, v 36(10), pp 2342-2345
Oct 1992
PMID: 1444316
url
https://doi.org/10.1128/aac.36.10.2342View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Anti-Bacterial Agents - pharmacology Depsipeptides Drug Resistance, Microbial Enterococcus - drug effects Microbial Sensitivity Tests Peptides, Cyclic
Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin.

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Collaboration types
Domestic collaboration
Web of Science research areas
Microbiology
Pharmacology & Pharmacy
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