Journal article
Barrett's esophagus: clinical characteristics
Gastroenterology clinics of North America, v 31(2), pp 441-460
Jun 2002
PMID: 12134612
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Barrett's metaplasia develops in 6-14% of individuals with gastroesophageal reflux. Barrett's adenocarcinomas are increasing in epidemic proportions for as yet unknown reasons, approximately 0.5-1% of patients with Barrett's will develop adenocarcinoma. Heartburn duration and frequency (but not severity), male gender, and Caucasian race are major risk factors for developing cancer. Obesity and smoking are weak risk factors. Survival is determined by depth of tumor invasion (stage). Once invasion of the muscularis propia occurs, the vast majority of patients will have developed widespread metastasis, even when clinical staging studies are negative. No currently available therapy results in prolonged survival once metastases develop. Thus, the more widespread use of effective surveillance strategies is the only currently available means for reducing the morbidity and mortality associated with Barrett's adenocarcinoma.
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Details
- Title
- Barrett's esophagus: clinical characteristics
- Creators
- James C Reynolds - Hahnemann University HospitalPoneh Rahimi - Hahnemann University HospitalDavid Hirschl - Hahnemann University Hospital
- Publication Details
- Gastroenterology clinics of North America, v 31(2), pp 441-460
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000176795000006
- Scopus ID
- 2-s2.0-0035992185
- Other Identifier
- 991019353629404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology