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Journal article
Basal ganglia modulation of thalamocortical relay in Parkinson's disease and dystonia
Frontiers in computational neuroscience, v 7, pp 124-124
05 Sep 2013
PMID: 24046745
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Basal ganglia dysfunction has being implied in both Parkinson's disease and dystonia. While these disorders probably involve different cellular and circuit pathologies within and beyond basal ganglia, there may be some shared neurophysiological pathways. For example, pallidotomy and pallidal Deep Brain Stimulation (DBS) are used in symptomatic treatment of both disorders. Both conditions are marked by alterations of rhythmicity of neural activity throughout basal ganglia-thalamocortical circuits. Increased synchronized oscillatory activity in beta band is characteristic of Parkinson's disease, while different frequency bands, theta and alpha, are involved in dystonia. We compare the effect of the activity of GPi, the output nuclei of the basal ganglia, on information processing in the downstream neural circuits of thalamus in Parkinson's disease and dystonia. We use a data driven computational approach, a computational model of the thalamocortical (TC) cell modulated by experimentally recorded data, to study the differences and similarities of thalamic dynamics in dystonia and Parkinson's disease. Our analysis shows no substantial differences in TC relay between the two conditions. Our results suggest that, similar to Parkinson's disease, a disruption of thalamic processing could also be involved in dystonia. Moreover, the degree to which TC relay fidelity is impaired is approximately the same in both conditions. While Parkinson's disease and dystonia may have different pathologies and differ in the oscillatory content of neural discharge, our results suggest that the effect of patterning of pallidal discharge is similar in both conditions. Furthermore, these results suggest that the mechanisms of GPi DBS in dystonia may involve improvement of TC relay fidelity.
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Details
- Title
- Basal ganglia modulation of thalamocortical relay in Parkinson's disease and dystonia
- Creators
- Yixin Guo - Drexel UniversityChoongseok Park - Indiana University – Purdue University IndianapolisRobert M. Worth - Indiana UniversityLeonid L. Rubchinsky - Indiana University – Purdue University Indianapolis
- Publication Details
- Frontiers in computational neuroscience, v 7, pp 124-124
- Publisher
- Frontiers Media Sa
- Number of pages
- 11
- Grant note
- R01NS067200 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Indiana University R01NS067200 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Drexel University DMS-1226180 / NSF; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mathematics
- Web of Science ID
- WOS:000324632600001
- Scopus ID
- 2-s2.0-84884685794
- Other Identifier
- 991019167645604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Mathematical & Computational Biology
- Neurosciences