Journal article
Basic research in epilepsy and aging
Epilepsy research, v 68(1), pp 21-37
2006
PMID: 16384687
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A PubMed search of the years 1965 to 2003 found only 30 articles that were directly related to modeling seizures or epilepsy in aged animals. This lack of research is disturbing but explainable because of the high cost of aged animals and their increasing infirmity. Many changes occur in the older brain: cell loss in the hippocampal formation, changes in long-term potentiation maintenance, alteration in kindling, increased susceptibility to status epilepticus, and neuronal damage from stroke. The effect of aging on voltage-gated sodium and calcium channels has not been studied sufficiently. With increasing numbers of elderly persons with epilepsy needing appropriate treatment, the need to better understand the basic mechanisms of epilepsy is crucial.
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Details
- Title
- Basic research in epilepsy and aging
- Creators
- Ilo E. Leppik - University of MinnesotaKevin M. Kelly - Drexel UniversityLeyla deToledo-Morrell - Rush University Medical CenterPeter R. Patrylo - Southern Illinois University CarbondaleRobert J. DeLorenzo - Virginia Commonwealth UniversityGary W. Mathern - University of California, Los AngelesH. Steve White - University of Utah
- Publication Details
- Epilepsy research, v 68(1), pp 21-37
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000235984000003
- Scopus ID
- 2-s2.0-31344471472
- Other Identifier
- 991019168844804721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology