Journal article
Bats and birds: Exceptional longevity despite high metabolic rates
Ageing research reviews, v 9(1), pp 12-19
01 Jan 2010
PMID: 19643206
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bats and birds live substantially longer on average than non-flying mammals of similar body size. The combination of small body size, high metabolic rates, and long lifespan in bats and birds would not seem to support oxidative theories of ageing that view senescence as the gradual accumulation of damage from metabolic byproducts. However, large-scale comparative analyses and laboratory studies on a few emerging model species have identified multiple mechanisms for resisting oxidative damage to mitochondrial DNA and cellular structures in both bats and birds. Here we review these recent findings, and suggest areas in which additional progress on ageing mechanisms can be made using bats and birds as novel systems. New techniques for determining the age of free-living, wild individuals, and robustly supported molecular phylogenies, are under development and will improve the efforts of comparative biologists to identify ecological and evolutionary factors promoting long lifespan. In the laboratory, greater development of emerging laboratory models and comparative functional genomic approaches will be needed to identify the molecular pathways of longevity extension in birds and bats. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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Details
- Title
- Bats and birds: Exceptional longevity despite high metabolic rates
- Creators
- Jason Munshi-South - BernardGerald S. Wilkinson - University of Maryland, College Park
- Publication Details
- Ageing research reviews, v 9(1), pp 12-19
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biodiversity, Earth, and Environmental Science (BEES)
- Web of Science ID
- WOS:000274616100002
- Scopus ID
- 2-s2.0-72149131462
- Other Identifier
- 991021903865304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology