Journal article
Bayesian modelling of lung cancer risk and bitumen fume exposure adjusted for unmeasured confounding by smoking
Occupational and environmental medicine (London, England), Vol.66(8), pp.502-508
Aug 2009
PMID: 19060029
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives:Residual confounding can be present in epidemiological studies because information on confounding factors was not collected. A Bayesian framework, which has the advantage over frequentist methods that the uncertainty in the association between the confounding factor and exposure and disease can be reflected in the credible intervals of the risk parameter, is proposed to assess the magnitude and direction of this bias.Methods:To illustrate this method, bias from smoking as an unmeasured confounder in a cohort study of lung cancer risk in the European asphalt industry was assessed. A Poisson disease model was specified to assess lung cancer risk associated with career average, cumulative and lagged bitumen fume exposure. Prior distributions for the exposure strata, as well as for other covariates, were specified as uninformative normal distributions. The priors on smoking habits were specified as Dirichlet distributions based on smoking prevalence estimates available for a sub-cohort and assumptions about precision of these estimates.Results:Median bias in this example was estimated at 13%, and suggested an attenuating effect on the original exposure–disease associations. Nonetheless, the results still implied an increased lung cancer risk, especially for average exposure.Conclusions:This Bayesian framework provides a method to assess the bias from an unmeasured confounding factor taking into account the uncertainty surrounding the estimate and from random sampling error. Specifically for this example, the bias arising from unmeasured smoking history in this asphalt workers’ cohort is unlikely to explain the increased lung cancer risk associated with average bitumen fume exposure found in the original study.
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Details
- Title
- Bayesian modelling of lung cancer risk and bitumen fume exposure adjusted for unmeasured confounding by smoking
- Creators
- F de Vocht - International Agency for Research on Cancer (IARC), Lyon, FranceH Kromhout - Environmental Epidemiology Group, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The NetherlandsG Ferro - International Agency for Research on Cancer (IARC), Lyon, FranceP Boffetta - International Agency for Research on Cancer (IARC), Lyon, FranceI Burstyn - Community and Occupational Medicine Program, Department of Medicine, Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, Canada
- Publication Details
- Occupational and environmental medicine (London, England), Vol.66(8), pp.502-508
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Identifiers
- 991014877808704721
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- Public, Environmental & Occupational Health