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Journal article
Bdnf DNA Methylation Modifications in the Hippocampus and Amygdala of Male and Female Rats Exposed to Different Caregiving Environments Outside the Homecage
Developmental psychobiology, v 56(8), pp 1755-1763
Dec 2014
PMID: 24752649
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have previously shown in infant rats that brief and repeated experiences with a stressed dam outside the homecage (maltreatment) alters methylation of DNA associated with the brain-derived neurotrophic factor (bdnf) gene within the developing and adult prefrontal cortex. BDNF is a key mediator of activity-dependent processes that have a profound influence on neural development and plasticity. Here we examined whether maltreatment also alters bdnf DNA methylation in two additional regions known to be prominently affected by diverse forms of early life adversity in humans- the hippocampus and amygdala. We found significant bdnf DNA methylation modifications present within the adult hippocampus (dorsal and ventral) and amygdala (central/basolateral complex). We observed that the nature of change differed between sexes, gene locus (bdnf I vs. IV), and brain region. Furthermore, a manipulation that did not produce any obvious behavior difference in infants (brief and repeated experiences with a nurturing foster dam) also had long-term effects on methylation. These data provide further empirical support of DNA methylation modifications as biological consequences of caregiving environments. (c) 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1755-1763, 2014.
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Details
- Title
- Bdnf DNA Methylation Modifications in the Hippocampus and Amygdala of Male and Female Rats Exposed to Different Caregiving Environments Outside the Homecage
- Creators
- Tania L. Roth - University of DelawareStephanie Matt - University of DelawareKenneth Chen - University of DelawareJennifer Blaze - University of Delaware
- Publication Details
- Developmental psychobiology, v 56(8), pp 1755-1763
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- University of Delaware Research Foundation 1P20GM103653 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Brain & Behavior Research Foundation; NARSAD P20GM103653 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000345312000013
- Scopus ID
- 2-s2.0-84911407698
- Other Identifier
- 991021902599204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Developmental Biology
- Psychology