Journal article
Bedtime insulin added to daytime sulfonylureas improves glycemic control in uncontrolled type II diabetes
Clinical pharmacology and therapeutics, v 53(3), pp 380-384
Mar 1993
PMID: 8453858
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: To evaluate the possible benefits of the addition of intermediate‐acting insulin administered at bedtime to therapy with daytime sulfonylureas in patients with non‐insulin‐dependent diabetes mellitus for whom maximal doses of oral hypoglycemic agents have not been successful.
Methods: Study subjects were 16 consecutive obese patients aged from 44 to 78 years (mean age, 62 years) with histories of non‐insulin‐dependent diabetes mellitus for a mean of 9 years. None of the subjects had been able to control their diabetes with maximal doses of oral hypoglycemic agents. All patients received 20 mg glipizide or 10 mg glyburide twice a day, as well as education about the American Diabetes Association diet. Neutral protamine Hagedorn (NPH) insulin was empirically added in doses from 0.1 to 0.2 units/kg given at bedtime. The dose was adjusted on the basis of fasting blood glucose levels.
Results: Mean fasting blood glucose decreased from 13.7 ± 3.4 to 8.3 ± 2.7 mmol/L at 3 months and 7.3 + 2.0 mmol/L at 1 year. Glycosylated hemoglobin decreased from 9.0% ± 1.9% to 6.2% ± 1.16% at 3 months and 6.3% ± 1.22% at 1 year.
Conclusion: A late‐night dose of NPH insulin was added to a regimen of daytime sulfonylureas in a group of obese patients with type II diabetes whose hyperglycemia was not controlled with maximal doses of oral hypoglycemic agents. This treatment proved to be beneficial and is a useful alternative to conventional insulin therapy in this group of patients.
Clinical Pharmacology and Therapeutics (1993) 53, 380–384; doi:10.1038/clpt.1993.36
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Details
- Title
- Bedtime insulin added to daytime sulfonylureas improves glycemic control in uncontrolled type II diabetes
- Creators
- Jeffrey L Miller - Hahnemann University HospitalKarl Salman - Hahnemann University HospitalLeon H Shulman - Hahnemann University HospitalLeslie I Rose - Hahnemann University HospitalJacob L Miller - Management
- Publication Details
- Clinical pharmacology and therapeutics, v 53(3), pp 380-384
- Publisher
- Springer Nature
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Management
- Web of Science ID
- WOS:A1993KU55300014
- Scopus ID
- 2-s2.0-0027394376
- Other Identifier
- 991019183951304721
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- Web of Science research areas
- Pharmacology & Pharmacy