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Journal article
Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
Frontiers in human neuroscience, v 8, pp 921-921
20 Nov 2014
PMID: 25477802
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to facilitate clinical trials aiming at treatments that attack the disease at its earliest stage or even prevent it. The increasing number of such biomarkers currently tested and now partly proposed for clinical implementation calls for critical reflection on their aims, social benefits, and risks. This position paper summarizes major challenges and responsibilities. Its focus is on the ethical and social problems involved in the organization and application of dementia research, as well as in healthcare provision from a cross-national point of view. The paper is based on a discussion of leading dementia experts from neuroscience, neurology, social sciences, and bioethics in the United States and Europe. It thus reflects a notable consensus across various disciplines and national backgrounds. We intend to initiate a debate on the need for actions within the researchers’ national and international communities.
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Details
- Title
- Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
- Creators
- Silke Schicktanz - University of GöttingenMark Schweda - University of GöttingenJesse F. Ballenger - Drexel UniversityPatrick J. Fox - University of California, San FranciscoJodi Halpern - University of California, BerkeleyJoel H. Kramer - Memory and Aging Center, Sandler Neurosciences Center, University of California San Francisco, San Francisco, CA, USA.Guy Micco - University of California, BerkeleyStephen G. Post - Stony Brook MedicineCharis Thompson - University of California, BerkeleyRobert T. Knight - Department of Psychology, University of California, Berkeley Helen Wills Neuroscience Institute, University of CaliforniaWilliam J. Jagust - Helen Wills Neuroscience Institute
- Publication Details
- Frontiers in human neuroscience, v 8, pp 921-921
- Publisher
- Frontiers Media S.A
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Administration
- Web of Science ID
- WOS:000345079900001
- Other Identifier
- 991019169713404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Psychology