Journal article
Behavior Matters-Cognitive Predictors of Survival in Amyotrophic Lateral Sclerosis
PloS one, v 8(2), pp e57584-e57584
27 Feb 2013
PMID: 23460879
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: It is difficult to longitudinally characterize cognitive impairment in amyotrophic lateral sclerosis (ALS) due to motor deficits, and existing instruments aren't comparable with assessments in other dementias.
Methods: The ALS Brief Cognitive Assessment (ALS-BCA) was validated in 70 subjects (37 with ALS) who also underwent detailed neuropsychological analysis. Cognitive predictors for poor survival were then analyzed in a longitudinal cohort of 171 ALS patients.
Results: The ALS-BCA was highly sensitive (90%) and specific (85%) for ALS-dementia (ALS-D). ALS-D patients had shorter overall survival, primarily due to the poor survival among ALS-D patients with disinhibited or apathetic behaviors after adjusting for demographic variables, ALS site of onset, medications, and supportive measures. ALS-D without behavioral changes was not a predictor of poor survival.
Conclusion: ALS-D can present with or without prominent behavioral changes. Cognitive screening in ALS patients should focus on behavioral changes for prognosis, while non-behavioral cognitive impairments may impact quality of life without impacting survival.
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Details
- Title
- Behavior Matters-Cognitive Predictors of Survival in Amyotrophic Lateral Sclerosis
- Creators
- William T. Hu - Emory UniversityMatthew Shelnutt - Emory UniversityAshley Wilson - Emory UniversityNicole Yarab - Emory UniversityCrystal Kelly - Emory UniversityMurray Grossman - University of PennsylvaniaDavid J. Libon - Drexel UniversityJaffar Khan - Emory UniversityJames J. Lah - Emory UniversityAllan I. Levey - Emory UniversityJonathan Glass - Emory University
- Publication Details
- PloS one, v 8(2), pp e57584-e57584
- Publisher
- Public Library Science
- Number of pages
- 8
- Grant note
- P50AG025688 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Viretta Brady Discovery Fund at Emory University School of Medicine AG025688 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000315519000134
- Scopus ID
- 2-s2.0-84874522112
- Other Identifier
- 991021901314704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology