Journal article
Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: Comparison with directly acting 5-HT agonists
Brain research bulletin, v 25(6), pp 953-960
1990
PMID: 2149668
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The 5-HT uptake inhibitor, sertraline (5–40 μmol/kg, IP) reduced the volume of milk consumed by food-deprived rats during a 30-min test (ID
50 = 12 μmol/kg). Observations using a time-sampling method revealed that sertraline shortened meal duration (ID
50 = 14 μmol/kg) by decreasing feeding and increasing resting without altering nonfeeding activity or the overall sequence of behavior that characterizes normal satiety. In separate experiments, analysis of videotapes demonstrated that sertraline (10 μmol/kg) decreased not only the time that rats fed but also their actual rate of intake. In comparison, doses of the direct 5-HT agonists, mCPP (1-[3-chlorophenyl]piperazine), RU 24969 (5-methoxy-3-[1,2,3,6-tetrahydropyridin-4-yl]-1H-indole), and DOI (1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane) that produced similar anorectic effects altered either feeding time or rate but not both. DOI also disrupted the continuity of feeding and the 5-HT agonist, 8-OH-DPAT (8-hydroxy-di-N-propylamino tetralin) produced marked stereotypy at anorectic doses. Together, these results imply that stimulating a number of different serotonergic mechanisms can reduce food intake in rats. Sertraline appears to accelerate the onset of normal satiety, presumably by enhancing physiological actions of endogenous 5-HT.
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Details
- Title
- Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: Comparison with directly acting 5-HT agonists
- Creators
- K.J SimanskyA.H Vaidya
- Publication Details
- Brain research bulletin, v 25(6), pp 953-960
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1990EQ10200022
- Scopus ID
- 2-s2.0-0025610262
- Other Identifier
- 991014878381204721
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- Web of Science research areas
- Neurosciences