Journal article
Bench to Bedside Tumor Necrosis Factor‐alpha: From Inflammation to Resuscitation
Academic emergency medicine, v 7(8), pp 930-941
Aug 2000
PMID: 10958139
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
. Proinflammatory mediators such as tumor necrosis factor‐alpha (TNF) have been implicated in the pathophysiology in a number of acute disease states. Tumor necrosis factor‐alpha can contribute to cell death, apoptosis, and organ dysfunction. Tumor necrosis factor‐alpha can be generated with sepsis or ischemia‐reperfusion by activation of cell mitogen‐activated protein kinases and nuclear factor kappa B, leading to TNF production. A number of strategies to modulate TNF have been recently explored, including factors directed toward mitogen‐activated protein kinases, TNF transcription, anti‐inflammatory ligands, heat shock proteins, and TNF‐binding proteins. However, TNF may also play an important role in the adaptive response to injury and inflammation. Control of the deleterious effects of TNF and other proinflamatory cytokines represents a realistic goal for clinical emergency medicine. The purpose of this article is to provide a background of relevance to emergency medicine academicians on the production and regulation of TNF, the acute effects of TNF on pathophysiology, and the rationale for therapeutic interventions directed toward TNF and the clinical experience with these strategies.
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Details
- Title
- Bench to Bedside Tumor Necrosis Factor‐alpha: From Inflammation to Resuscitation
- Creators
- Charles B. Cairns - University of Colorado HealthEdward A. Panacek - University of California, DavisAlden H. Harken - University of Colorado HealthAnirban Banerjee - University of Colorado Health
- Publication Details
- Academic emergency medicine, v 7(8), pp 930-941
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000088910200015
- Scopus ID
- 2-s2.0-0033902973
- Other Identifier
- 991021463430504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Emergency Medicine